Registered Nurse Salary in San Antonio, TX (2026)
Median Registered Nurse salary in San Antonio is approximately $80,000/year — 7.0% below the US national average.
Salary breakdown — San Antonio
After-tax estimate
| City | Cost mult. | Estimated annual | vs San Antonio |
|---|---|---|---|
| Grand Rapids, MI | 0.93× | $80,000 | +$0 |
| Milwaukee, WI | 0.94× | $80,800 | +$800 |
| Albuquerque, NM | 0.94× | $80,800 | +$800 |
| New Orleans, LA | 0.94× | $80,800 | +$800 |
| Columbus, OH | 0.92× | $79,100 | -$900 |
Registered Nurse salaries in San Antonio, TX
The estimated median Registered Nurse salary in San Antonio, Texas is $80,000/year, working out to approximately $38/hour at full-time, $3,077 per biweekly paycheck, or $6,667/month before taxes. San Antonio's cost-of-living multiplier of 0.93× national reflects local prices, housing costs, and employer concentration in this metro area.
Compared to the Texas state average for this role ($83,400), San Antonio pays about $3,400 less. This typically reflects how the metro area's cost of living and employer density differ from the state as a whole.
Take-home pay in San Antonio
Of the gross $80,000, you take home roughly $62,680 after:
- Federal income tax (~14% effective at this income)
- FICA — Social Security 6.2% + Medicare 1.45% = 7.65%
- Texas state income tax (none)
- San Antonio has no local income tax
That works out to about $5,223/month after-tax — useful for budgeting rent (typically 25–35% of net income), savings (15–20% target), and other expenses. For an exact calculation including 401(k), HSA, and your filing status, use our San Antonio Paycheck Calculator.
What affects your actual pay
- Experience: entry-level often 25–35% below median; senior roles 40–60%+ above.
- Specific employer: top-tier employers in San Antonio pay 10–25% above market for the same role.
- Industry: a Software Engineer at a tech company in San Antonio typically out-earns one at a non-tech employer.
- Negotiation: simply negotiating an offer can shift comp by 5–15%.
- Education and credentials: degrees and licenses (especially for healthcare, legal, engineering) can move comp by 15–30%.
- Remote vs in-office: many San Antonio employers now base pay on cost of living, with remote workers in cheaper metros paid less.
Related calculators
Registered Nurse Salary in Texas — state-level average. Salary Calculator — convert hourly ↔ annual. San Antonio Paycheck Calculator — exact take-home. Income Tax Calculator — federal tax with brackets. Investment Calculator — long-term portfolio growth.